| Saturday 8 July 2017 | Away | Easthouses Lily MW v Preston Athletic | Pre-Season Friendly | Broadhurst Road, Easthouses | 0-4 |
| Tuesday 11 July 2017 | Home | Preston Athletic v Penicuik Athletic | Pre-Season Friendly | Middleshot 3G, Prestonpans | 2-5 |
| Saturday 15 July 2017 | Home | Preston Athletic v Edinburgh University | Pre-Season Friendly | Middleshot 3G, Prestonpans | 3-1 |
| Tuesday 18 July 2017 | Home | Preston Athletic v Dalkeith Thistle | Pre-Season Friendly | Pennypit Park, Prestonpans | 4-1 |
| Saturday 22 July 2017 | Home | Preston Athletic v Tranent Juniors | Pre-Season Friendly | Pennypit Park, Prestonpans | 1-6 |
| Tuesday 25 July 2017 | Home | Preston Athletic v Dunbar Utd | Pre-Season Friendly | Pennypit Park, Prestonpans | 1-1 |
| Saturday 29 July 2017 | FREE WEEK | ||||
| Tuesday 1 Aug 2017 | Home | Preston Athletic v Ormiston | East of Scotland Qualifying League Section D | Pennypit Park, Prestonpans | 5-1 |
| Saturday 5 Aug 2017 | Away | Coldstream v Preston Athletic | East of Scotland Qualifying League Section D | Home Park, Coldstream | 1-2 |
| Saturday 12 Aug 2017 | Away | Vale of Leithen v Preston Athletic | FN East of Scotland Qualifying Cup R2 William Hill Scottish Cup PreLim R1 (Bye) |
Victoria Park, Innerleithen | 3-0 |
| Saturday 19 Aug 2017 | Away | Leith Athletic v Preston Athletic | Central Taxis East of Scotland League | Meadowbank 3G, Edinburgh | 2-0 |
| Tuesday 22 Aug 2017 | Home | Preston Athletic v Tweedmouth Rangers | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 7:30 k/o |
| Saturday 26 Aug 2017 | Home | Preston Athletic v Peebles Rovers | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 2 Sept 2017 | Away | Colville Park AFC v Preston Athletic | William Hill Scottish Cup PreLim R2 | 3G New Tinto Park, Glasgow | 3:00 k/o |
| Saturday 9 Sept 2017 | Away | Coldstream v Preston Athletic | Central Taxis East of Scotland League | Home Park, Coldstream | 2:30 k/o |
| Saturday 16 Sept 2017 | Home | Preston Athletic v Burntisland Shipyard | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 23 Sept 2017 | William Hill Scottish Cup R1 | ||||
| Saturday 30 Sept 2017 | Home | Preston Athletic v Eyemouth Utd | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 7 Oct 2017 | Away | Ormiston v Preston Athletic | Central Taxis East of Scotland League | Ormiston | 2:30 k/o |
| Saturday 14 Oct 2017 | Away | Heriot Watt Uni v Preston Athletic | Central Taxis East of Scotland League or William Hill Scottish Cup R2 |
Oriam, Riccarton | 3:00 k/o |
| Saturday 21 Oct 2017 | Away | Leith Athletic/Heriot Watt Uni v Preston Athletic | South Challenge Cup R2 | TBC | 3:00 k/o |
| Saturday 28 Oct 2017 | TBC | Preston Athletic v TBC | Central Taxis East of Scotland League | TBC | TBC |
| Saturday 4 Nov 2017 | Home | Preston Athletic v Tynecastle | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 11 Nov 2017 | TBC | Preston Athletic v TBC | South Challenge Cup R3 or FN East of Scotland Qualifying Cup or Central Taxis East of Scotland League | TBC | TBC |
| Saturday 18 Nov 2017 | Away | Stirling Uni v Preston Athletic | Central Taxis East of Scotland League or William Hill Scottish Cup R3 |
Stirling | 2:30 k/o |
| Saturday 25 Nov 2017 | Away | Kelty Hearts v Preston Athletic | Central Taxis East of Scotland League or William Hill Scottish Cup R2 |
New Central Park, Kelty | 2:30 k/o |
| Saturday 2 Dec 2017 | TBC | TBC | FN East of Scotland Qualifying Cup or Central Taxis East of Scotland League |
TBC | TBC |
| Saturday 9 Dec 2017 | Home | Preston Athletic v Lothian Thistle HV | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 16 Dec 2017 | Away | Eyemouth Utd v Preston Athletic | Central Taxis East of Scotland League | Warner Park, Eyemouth | 2:00 k/o |
| Saturday 6 Jan 2018 | Home | Preston Athletic v Ormiston | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 13 Jan 2018 | Away | Tynecastle v Preston Athletic | Central Taxis East of Scotland League | Saughton Park, Edinburgh | 2:30 k/o |
| Saturday 20 Jan 2018 | Home | Preston Athletic v Leith Athletic | Central Taxis East of Scotland League or William Hill Scottish Cup R4 or FN East of Scotland Qualifying Cup S/F |
Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 27 Jan 2018 | Away | Tweedmouth Rangers v Preston Athletic | Central Taxis East of Scotland League | Old Shielfield, Berwick | 2:00 k/o |
| Saturday 3 Feb 2018 | Away | Peebles Rovers v Preston Athletic | Central Taxis East of Scotland League | Whitestone Park, Peebles | 2:30 k/o |
| Saturday 10 Feb 2018 | Home | Preston Athletic v Heriot Watt Uni | Central Taxis East of Scotland League William Hill Scottish Cup R5 |
Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 17 Feb 2018 | Home | Preston Athletic v Stirling Uni | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 2:30 k/o |
| Saturday 24 Feb 2018 | TBC | TBC | Central Taxis East of Scotland League | TBC | TBC |
| Saturday 3 Mar 2018 | Away | Peebles Rovers v Preston Athletic | King Cup R1 William Hill Scottish Cup R6 |
Whitestone Park, Peebles | 2:30 k/o |
| Saturday 10 Mar 2018 | Home | Preston Athletic v Coldstream | Central Taxis East of Scotland League | Pennypit Park, Prestonpans | 2:30 k/o |
| Tuesday 13 Mar 2018 | Berwick Rangers v EOS Qualifying Cup Finalist | East of Scotland Cup Semi Final | |||
| Wednesday 14 Mar 2018 | Edinburgh City v EOS Qualifying Cup Finalist | East of Scotland Cup Semi Final | |||
| Saturday 17 Mar 2018 | Away | Burntisland Shipyard v Preston Athletic | Groundhop Day #2 Central Taxis East of Scotland League | Recreation Park, Burntisland | 11:00 k/o |
| Saturday 24 Mar 2018 | Home | Peebles/Preston Athletic v Ormiston | King Cup R2 | Pennypit Park, Prestonpans | 2:30 k/o |
| Sunday 25 Mar 2018 | FN East of Scotland Qualifying Cup Final | ||||
| Saturday 31 Mar 2018 | South Challenge Cup Semi Finals | ||||
| Sunday 8 Apr 2018 | Central Taxis East of Scotland League Cup Final | ||||
| Tuesday 10 Apr or Wednesday 11 Apr 2018 |
East of Scotland Cup Final | ||||
| Saturday 14 Apr 2018 | William Hill Scottish Cup Semi Finals King Cup Semi Finals |
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| Saturday 5 May 2018 | Lowland League Promotion PlayOff 1st Leg | ||||
| Saturday 12 May 2018 | Lowland League Promotion PlayOff 2nd Leg | ||||
| Saturday 19 May 2018 | William Hill Scottish Cup Final | ||||
| Sunday 20 May 2018 | South Challenge Cup Final | ||||
| Saturday 26 May 2018 | King Cup Final |