| Thursday 12 July 2018 | Home | Preston Athletic v Berwick Rangers Reserves | Pre-Season Friendly | Pinkie 3G, Musselburgh | 4-3 |
| Tuesday 17 July 2018 | Home | Preston Athletic v Newtongrange Star | Pre-Season Friendly | Pinkie 3G, Musselburgh | 1-3 |
| Thursday 19 July 2018 | Home | Preston Athletic v Danderhall Miners AFC | Pre-Season Friendly | Pennypit Park, Prestonpans | 8-1 |
| Saturday 21 July 2018 | Away | Livingston Utd v Preston Athletic | Pre-Season Friendly | Station Park, Deans, Livingston | 0-0 |
| Tuesday 24 July 2018 | Away | Whitehill Welfare v Preston Athletic | MATCH CANCELLED | ||
| Saturday 28 July 2018 | Home | Preston Athletic v Musselburgh Athletic | East of Scotland Qualifying League Section H | Pennypit Park, Prestonpans | 0-3 |
| Wednesday 1 Aug 2018 | Away | Dunipace v Preston Athletic | East of Scotland Qualifying League Section H | Carmuirs Park, Fairlie Drive, Camelon, FK1 4NP | 3-1 |
| Saturday 4 Aug 2018 | Away | Burntisland Shipyard v Preston Athletic | East of Scotland Qualifying League Section H | Recreation Park, Burntisland | 1-2 |
| Saturday 11 Aug 2018 | Home | Preston Athletic v Glasgow University | William Hill Scottish Cup PreLim R1 | Pennypit Park, Prestonpans | 3-1 |
| Saturday 18 Aug 2018 | Home | Preston Athletic v St Andrew’s Utd | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 2-2 |
| Tuesday 21 Aug 2018 | Home | Preston Athletic v Blackburn Utd | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 4-3 |
| Saturday 25 Aug 2018 | Away | Jeanfield Swifts v Preston Athletic | Central Taxis East of Scotland League Conference C | Riverside Stadium, Bute Road, Perth | 6-1 |
| Saturday 1 Sept 2018 | Home | Preston Athletic v Linlithgow Rose | William Hill Scottish Cup PreLim R2 | Pennypit Park, Prestonpans | 0-2 |
| Tuesday 4 Sept 2018 | Home | Preston Athletic v Dunbar Utd | Friendly | Pennypit Park, Prestonpans | 1-3 |
| Saturday 8 Sept 2018 | Away | Ormiston v Preston Athletic | Central Taxis East of Scotland League Conference C | New Recreation Park, Ormiston | 2-4 |
| Saturday 15 Sept 2018 | Away | Bonnyton Thistle v Preston Athletic | SFA South Region Challenge Cup R2 | Harriet Road, Kilmarnock | 2-3 |
| Saturday 22 Sept 2018 | Away | Inverkeithing Hillfield Swifts v Preston Athletic | Central Taxis East of Scotland League Conference C | Ballast Bank Pavilion, Preston Street, Inverkeithing, KY11 1DS | 3-5 |
| Saturday 29 Sept 2018 | Home | Preston Athletic v Broxburn Athletic | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 1-4 |
| Saturday 6 Oct 2018 | Away | Linlithgow Rose v Preston Athletic | Central Taxis East of Scotland League Conference C | Prestonfield, Linlithgow | 5-0 |
| Saturday 13 Oct 2018 | Away | Inverkeithing Hillfield Swifts v Preston Athletic | SFA South Region Challenge Cup R3 | Ballast Bank Pavilion, Preston Street, Inverkeithing, KY11 1DS | 2-4 |
| Saturday 20 Oct 2018 | Home | Preston Athletic v Heriot Watt University | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 4-1 |
| Saturday 27 Oct 2018 | Away | Stirling University v Preston Athletic | Central Taxis East of Scotland League Conference C | Gannochy Sports Centre, Stirling University | 2-2 |
| Tuesday 30 Oct 2018 | Away | Broxburn Athletic v Preston Athletic | FN East of Scotland Qualifying Cup R2 | Albyn Park, Greendykes Road, Broxburn | 2-1 |
| Saturday 3 Nov 2018 | FREE WEEK | ||||
| Saturday 10 Nov 2018 | Away | East Kilbride v Preston Athletic | SFA South Region Challenge Cup R4 | K Park, Calderglen, East Kilbride | 5-0 |
| Saturday 17 Nov 2018 | Home | Preston Athletic v Craigroyston | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 1-2 |
| Saturday 24 Nov 2018 | Away | Edinburgh Utd v Preston Athletic | Central Taxis East of Scotland League Conference C | Paties Road, Edinburgh | 1-4 |
| Saturday 1 Dec 2018 | Home | Preston Athletic v Linlithgow Rose | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 3-5 |
| Saturday 8 Dec 2018 | Home | Preston Athletic v Inverkeithing Hillfield Swifts | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 3-0 |
| Saturday 15 Dec 2018 | Away | Camelon v Preston Athletic | Central Taxis East of Scotland League Conference C | Carmuirs Park, Falkirk | P-P |
| Saturday 22 Dec 2018 | Home | Preston Athletic v Easthouses Lily | Friendly | Middleshot 3G, Prestonpans | 0-1 |
| Saturday 29 Dec 2018 | Home | Preston Athletic v Edinburgh Utd | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | P-P |
| Saturday 5 Jan 2019 | Home | Preston Athletic v Ormiston | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 4-1 |
| Tuesday 8 Jan 2019 | Home | Preston Athletic v Edinburgh Utd | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 4-1 |
| Saturday 12 Jan 2019 | Away | Craigroyston v Preston Athletic | Central Taxis East of Scotland League Conference C | St Mark’s Park, Edinburgh | 3-2 |
| Saturday 19 Jan 2019 | Home | Preston Athletic v Stirling University | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 1-1 |
| Tuesday 22 Jan 2019 | Home | Preston Athletic v Newcraighall Leith Victoria | Friendly | Pennypit Park, Prestonpans | 4-0 |
| Saturday 26 Jan 2019 | Away | Broxburn Athletic v Preston Athletic | Central Taxis East of Scotland League Conference C | Albyn Park, Broxburn | 0-2 |
| Saturday 2 Feb 2019 | Away | St Andrew’s Utd v Preston Athletic | POSTPONED | Barnetts Park, Langlands Road, St Andrews, KY16 8BN | P-P |
| Saturday 2 Feb 2019 | Home | Preston Athletic v Whitehill Welfare | Friendly | Middleshot 3G, Prestonpans | 2-1 |
| Saturday 9 Feb 2019 | Home | Preston Athletic v Haddington Athletic | King Cup R1 | Pennypit Park, Prestonpans | 1-2 |
| Saturday 16 Feb 2019 | Away | Heriot Watt University v Preston Athletic | Central Taxis East of Scotland League Conference C | Oriam, Riccarton, Edinburgh | 1-2 |
| Saturday 23 Feb 2019 | Home | Preston Athletic v Jeanfield Swifts | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 0-3 |
| Saturday 2 Mar 2019 | Home | Preston Athletic v Dalkeith Thistle | Friendly | Dalkeith Campus 3G | 4-2 |
| Saturday 9 Mar 2019 | Away | Camelon v Preston Athletic | Central Taxis East of Scotland League Conference C | Carmuirs Park, Falkirk | 4-1 |
| Saturday 16 Mar 2019 | FREE WEEK | ||||
| Tuesday 19 Mar 2019 | Home | Preston Athletic v Camelon | Central Taxis East of Scotland League Conference C | Pennypit Park, Prestonpans | 0-0 |
| Saturday 23 Mar 2019 | Away | St Andrew’s Utd v Preston Athletic | Central Taxis East of Scotland League Conference C | Barnetts Park, Langlands Road, St Andrews | 1-1 |
| Saturday 30 Mar 2019 | Away | Blackburn Utd v Preston Athletic | Groundhop Day #2 Central Taxis East of Scotland League Conference C | New Murrayfield Park 3G, Blackburn | 4-1 |
| Saturday 6 Apr 2019 | |||||
| Saturday 13 Apr 2019 | |||||
| Saturday 20 Apr 2019 | |||||
| Saturday 27 Apr 2019 | Central Taxis East of Scotland League Title Round Robin | ||||
| Saturday 4 May 2019 | Central Taxis East of Scotland League Title Round Robin | ||||
| Sunday 5 May 2019 | Central Taxis East of Scotland League Cup Final | ||||
| Saturday 25 May 2019 | William Hill Scottish Cup Final | ||||
| Sunday 26 May 2019 | South Challenge Cup Final | ||||
| Saturday 1 June 2019 | King Cup Final |