| Monday 9 July 2018 | Away | Musselburgh Athletic u20 v Preston Athletic u20 |
Pre-Season Friendly | Pinkie 3G, Musselburgh | |
| Wednesday 11 July 2018 | Away | Preston Athletic u20 v East Lothian Thistle Amateurs |
Pre-Season Friendly | Jack Kane Centre, Edinburgh | 2-5 |
| Monday 30 July 2018 | Home | Preston Athletic u20 v Ormiston Amateurs |
Pre-Season Friendly | Pennypit Park, Prestonpans | 0-6 |
| Thursday 2 August 2018 | Home | Preston Athletic u20 v Musselburgh Windsor u19 | Pre-Season Friendly | Pennypit Park, Prestonpans | 3-4 |
| Tuesday 7 August 2018 | Away | Pathhead Amateurs v Preston Athletic u20 | Pre-Season Friendly | Callander Park, Pathhead | 5-1 |
| Friday 17 August 2018 | Home | Preston Athletic u20 v Lothian Thistle HV u20 | Qualifying League Section D |
peffermill 3G | 7.45pm |
| Friday 24 August 2018 | Home | FREE WEEK | |||
| Friday 31 August 018 | Home | Preston Athletic u20 v Camelon u20 | Scottish Youth Cup R1 (Bye) Qualifying League Section D |
Pennypit Park, Prestonpans | 8.00pm |
| Friday 7 September 2018 | Away | Spartans u20 v Preston Athletic u20 | Qualifying League Section D |
Ainslie Park, Edinburgh | 8.00pm |
| Friday 14 September 2018 | Away | Dalkeith Thistle u20 v Preston Athletic u20 | Qualifying League Section D |
King’s Park, Dalkeith | 8.00pm |
| Friday 21 September 2018 | Home | Preston Athletic u20 v Kelty Hearts u20 | League Conference A | Pennypit Park, Prestonpans | 8.00pm |
| Friday 28 September 2018 | Away | Kelty Hearts u20 or Partick thistle u20 v Preston Athletic u20 | Scottish Youth Cup R2 |
TBC | TBC |
| Friday 5 October 2018 | Away | Whitehill Welfare u20 v Preston Athletic u20 | League Conference A | Lasswade High School 3G | 7.45pm |
| Friday 12 October 2018 | FREE WEEK | ||||
| Friday 19 October 2018 | Away | Heriot Watt Uni u20 v Preston Athletic u20 | League Conference A | Oriam, Riccarton | 8.00pm |
| Friday 26 October 2018 | Home | Preston Athletic u20 v Hill of Beath Hawthorn u20 | League Conference A | Pennypit Park, Prestonpans | 8.00pm |
| Friday 2 November 2018 | Away | Tynecastle u20 v Preston Athletic u20 | League Conference A | Saughton 3G, Edinburgh | 8.00pm |
| Friday 9 November 2018 | Home | Preston Athletic u20 v Bonnyton Thistle u20 | Scottish Youth Cup R3 League Conference A |
Pennypit Park, Prestonpans | 8.00pm |
| Friday 16 November 2018 | Away | Camelon u20 v Preston Athletic u20 | League Conference A | 3G Little Kerse, Grangemouth | 8.00pm |
| Friday 23 November 2018 | Home | Preston Athletic u20 v Cumbernauld Colts u20 | League Conference A | Pennypit Park, Prestonpans | 8.00pm |
| Friday 30 November 2018 | Away | Dunipace u20 v Preston Athletic u20 | League Conference A | Westfield Park, Denny | 8.00pm |
| Friday 7 December 2018 | Home | Preston Athletic u20 v Edinburgh University u20 | Scottish Youth Cup R4 League Conference A |
Pennypit Park, Prestonpans | 8.00pm |
| Friday 14 December 2018 | Away | Gala Fairydean Rovers u20 v Preston Athletic u20 | League Conference A | Netherdale 3G, Galashiels | 8.15pm |
| CHRISTMAS BREAK | |||||
| Friday 4 January 2019 | Away | Kelty Hearts u20 v Preston Athletic u20 | League Conference A | New Central Park, Kelty | 8.00pm |